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D

Dasatinib = generic name for the SRC kinase inhibitor marketed under the brand name of Sprycel from Bristol Myers Squibb. Dasatinib is indicated for patients who develop resistance with Gleevec or are intolerant of Gleevec.  It is 300 times more potent than Gleevec.

*Deep Molecular Response = 4.5 reduction of bcr-abl transcript level as measured by PCR

Diff = differential white blood count = a relative count of the different white blood cells types in a blood sample.  A “normal” diff might be 60% neutrophils (or “poly’s”); 35% lymphocytes (lymphs); 2% monocytes (monos); 1% basophils (basos); 1% eosinophils (eos).

*DLI = Donor Leukocyte Infusion.

DNA = Molecule that carries genetic information. The DNA is assembled into discrete packets called chromosomes. Humans have 23 pairs of chromosomes, or 46 of them, total, in each cell.

*Donor Leukocyte Infusion =

a procedure done for relapsed SCTs. Immune system cells are taken from the original donor and transfused to the CML patient. See also http://www.haem.net/clinical/clinical012.asp

*Durable = long lasting; the term is used in qualifying response to therapy: a durable response to Gleevec, for example, is one that lasts.

*Dx = abbreviation for “diagnosis”