CML Glossary ‘G’



*G-CSF = granulocyte colony stimulating factor (brand name Neupogen) = a naturally occurring hormone that stimulates white blood cell production


Generic imatinib = a formulation of imatinib (Gleevec); in Canada this is made with the original alpha crystal formulation of imatinib (not tested in clinical trials) for which the patent expired in 2013 (in Canada) allowing for a generic version.  In Canada both Teva and Apotex manufacture a generic imatinib which has been approved by Health Canada.


*GEP = Gene Expression Profiling: an experimental technique for determining which genes in a tissue sample are being over or under expressed. Patterns of over and under expression can help predict whether a cancer will or won’t spread, and what drugs will work

best against it.


*Gleevec = branded name for Novartis’ anti-CML drug. Gleevec works by binding to and inhibiting the bcr-abl enzyme that is the hallmark of this disease. Gleevec’s generic name is imatinib mesylate,

so it’s also referred to as IM.


*Glivec = the spelling used for Gleevec in some other countries other than the US and Canada.


*GM-CSF = Granulocyte-monocyte colony stimulating factor = a naturally occurring hormone that stimulates white blood cell production (in a different way than G-CSF does)


*Graft vs. host disease (GVHD) = a collection of ailments that complicate stem cell (bone marrow) transplantation. In GVHD, the donor’s immune system (the “graft”) attacks various parts of the patient’s (the host’s) tissues.


*Granulocyte = another name for a white blood cell


*GVHD = graft vs. host disease


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